The means of AMPK to stimulateGLUT4 translocation to matlab plasma membrane in skeletal muscle is by engineering different mechanismthan that inspired by insulin and insulin and AMPK effects are additive. Under ischemic/hypoxic circumstances in matlab heart matlab activation of AMPK leads to thephosphorylation and activation engineering matlab kinase exercise of phosphofructokinase 2, PFK 26 phosphofructo 2 kinase. The product engineering matlab action of PFK 2 fructose 2,6 bisphosphate,F2,6BP is one engineering matlab most powerful regulators engineering matlab rate of flux throughglycolysis and gluconeogenesis. In liver matlab PKA mediated phosphorylation of PFK 2 effects in conversion of theenzyme from engineering kinase that generates F2,6BP to engineering phosphatase that removes the2 phosphate thus reducing matlab levels engineering matlab powerful allosteric activator engineering matlab glycolyticenzyme 6 phosphfructo 1 kinase, PFK 1 and matlab strong allosteric inhibitorof matlab gluconeogenic enzyme fructose 1,6 bisphosphatase F1, 6BPase. It is vital to note that like many enzymes, there are varied isoforms of PFK 2at least 4 and neither matlab liver or matlab skeletal muscle isoforms comprise matlab AMPKphosphorylation sites found out in matlab cardiac and inducible iPFK2 isoforms of PFK 2. Inducible PFK 2 is expressed in matlab monocyte/macrophage lineage based on pro inflammatory stimuli.